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Semaglutide 101

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Reconstitution & dosing math for Semaglutide.

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01

Names & Brands

  • Semaglutide
  • Brand names: Wegovy®, Ozempic®, Rybelsus®
02

Your Body's Metabolic Remote Control

  • GLP-1 receptor agonist
  • Enhances insulin secretion on glucose spikes
  • Slows gastric emptying
  • Reduces glucagon
03

The Dosing Playbook: Start Low, Go Slow

  • Wegovy (weekly): 0.25mg for weeks 1-4 → 0.5mg (month 2) → 1.0mg (month 3) → 1.7mg (month 4) → 1.7-2.4mg maintenance (max 2.4mg).
  • Ozempic (weekly): 0.25mg × 4 weeks → 0.5mg → 1mg → 2mg, increasing at intervals of at least 4 weeks.
  • Rybelsus (oral) Regimen 1: 3mg × 30 days → 7mg → 14mg. Regimen 2: 1.5mg × 30 days → 4mg → 9mg. The two regimens are "NOT interchangeable".
04

Injection Mastery & Storage Hacks

  • Opened Ozempic pen: good for 56 days at room temperature or refrigerated (never freeze).
  • Opened Wegovy pen: good for 28 days (never freeze).
  • Inject into the abdomen, thigh, or upper arm; rotate sites; use the same day each week.
05

Real Talk: What Your Body Will Tell You

  • Gastrointestinal side effects: nausea, fullness, reflux, constipation/diarrhea.
  • Side effects are dose-dependent.
  • Dose holds are used to manage side effects.
06

Your Resource Arsenal

  • External: Wegovy dosing schedule, Quick-Start PDF, and FAQ.
  • External: Ozempic (NovoMedLink).
  • External: Rybelsus (Drugs.com, Medical News Today, GoodRx).
  • External: Mayo Clinic monograph; Healthline.
  • Internal: Every GLP-1 Medication Compared → /answer/glp-1-medications

This profile is being expanded — additional sections from the source are still being added.

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